软件应用

• 1脆性X:
  Automated Fragile X Analysis of Triplet CGG Repeats & Percent MethylationCompletely integrated analysis from genotyping through reporting provides: Faster, reduces analysis time by up to 50% Reduced Errors, no data transfer Accurate Fragile X Analysis

• 2.MLPA（多重链接探针扩增技术 ):
  Multiplex Ligation-dependent Probe Amplification (MLPA) is a rapid, high-throughput technique for detecting copy number changes, with both general and clinical researchapplications. Kits are commercially available through MRC Holland. GeneMarker® software provides an entire module dedicated to MLPA analysis in house, no internet needed. The MLPA analysis application is linked directly to the program, allowing the user to process raw data, normalize samples , and perform MLPA analysis all in one program - eliminating unnecessary data transfers.

• 3.MS-MLPA:
  GeneMarker® software DNA analysis software is compatible with all major CE genetic-analyzers, and is an excellent alternative to Coffalyser.Net, GeneMapper®, Genotyper™, GeneScan®, and CEQ™ Fragment Analysis Software for MLPA® for detecting genetic deletions and duplications associated with various diseases and cancers.

• 4. 染色体三体分析:
  software accepts all major CE output files, including: ABI-PRISM® (*.FSA,*AB1,*.ABI), SCF, MegaBace® (*.RSD,*.ESD), Beckman-Coulter files (*.CEQ) for aneuploidy/trisomy analysis. Aneuploidy occurs from non-disjunction during meiosis I or meiosis

• 5. 单体型分析:
  Importing ABI®PRISM, Beckman-Coulter® orMegaBACE® CE data to into GeneMarker software provides user friendly, accurate genotyping with a linked Haplotype Analysis application (avoids potential errors from data transfer from one software to another),

• 6. 杂合性缺失分析:
  LOH occurs when a somatic cell contains only one copy of an allele due to non-disjunction during mitosis, segregation during recombination, or deletion of a chromosome segment.

• 7.ARMs & Comparative Analysis（囊性纤维症):
  (Amplification Refractory Mutation System, Newton et al. 1989) allele specific amplification technology, detects point mutations, insertions or deletions in DNA.

• 8. 微卫星不稳定分析（MSI）:
  GeneMapper®, Genotyper™, GeneScan®, MegaBACE Genetic Profiler, CEQ™ Fragment Analysis Software; is directly linked to the main analysis screen and is an excellent tool for analysis from kits such as the

• 9. SNPWave®/SNPlex®

• 10. AFLP:
  Amplified Fragment Length Polymorphism is a PCR based genetic fingerprinting technique developed by KeyGene. AFLP technology has the capability to detect various polymorphisms in different genomic regions simultaneously,

• 11. t-RFLP:
  T-RFLP is a PCR based genetic fingerprinting technique for the study of microbial community structure based on variation in the 16S rRNA gene. These DNA fragments are commonly separated using capillary electrophoresis.

• 12. 微卫星（SSR、STR、VNTR）:
  Microsatellites (also known as simple-sequence-repeats, simple-tandem-repeats, variable-nucleotidetandem-repeats in eukaryote research; and Multiple-Loci-VNTR-Analysis in microbial research) are widely used to determine the genotype of organisms based onnaturally occurring variation.

• 13. 自然种群的亲缘关系分析及数据库:GeneMarker® software, genotyping software for DNA fragment data from ABI PRISM®,Beckman CEQ™ or MegaBACE™ capillary electrophoresis, includes a linked Kinship Analysis and database search module which enables ecologists, and other wildlife researchers to easily identify kinships in

• 14. MLVA:
  MLVA分析是利用VNTR（可变数目串联重复序列）分子分型方法，与真核生物的SSR和STR分析相似，使用范围从传播途径研究、耐药性（例如MRSA）到食品安全（沙门氏菌检测）和微生物来源追踪。MLAV比其他微生物鉴定方法有更高的分辨力（如荚膜多糖和表面蛋白的分型、Spa-sequence分型），扩增结果便于聚类分析。

• 15. TILLING®或EcoTilling（平板胶、 毛细管电泳均可）

• 16. SBE/SNapShot®

• 17. 快速分析工具：

• 18. 聚类分析

• 19. 大分子分析工具

• 20. 工程合并

应用指南下载：